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LUNESTA (ESZOPICLONE): DOSAGE AND ADMINISTRATION

The dose of Lunesta (Eszopiclone) tablets should be individualized. The recommended starting dose for Lunesta for most non-elderly adults is 2 mg immediately before bedtime. Dosing can be initiated at or raised to 3 mg if clinically indicated, since 3 mg is more effective for sleep maintenance.

The recommended starting dose of Lunesta (Eszopiclone) for elderly patients whose primary complaint is difficulty falling asleep is 1 mg immediately before bedtime. In these patients, the dose may be increased to 2 mg if clinically indicated. For elderly patients whose primary complaint is difficulty staying asleep, the recommended dose is 2 mg immediately before bedtime.

Taking Eszopiclone tablets with or immediately after a heavy, high-fat meal results in slower absorption and would be expected to reduce the effect of Lunesta on sleep latency.

Special Populations

Hepatic

The starting dose of Lunesta should be 1 mg in patients with severe hepatic impairment. Eszopiclone should be used with caution in these patients.

Coadministration with CYP3A4 Inhibitors

The starting dose of Eszopiclone should not exceed 1 mg in patients coadministered Lunesta with potent CYP3A4 inhibitors. If needed, the dose can be raised to 2 mg.

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